Stratification of rodent carcinogenicity bioassay results to reflect relative human hazard

Mutat Res. 1993 Mar;286(1):111-8. doi: 10.1016/0027-5107(93)90006-2.

Abstract

Trans-species, multiple site (particularly common site between species), mutagenic rodent carcinogens are less affected by the influences of polymorphic genes than are chemicals inducing more limited carcinogenic effects. Trans-species carcinogens, therefore, should represent a first priority for attention for human health risk.

Publication types

  • Review

MeSH terms

  • Animals
  • Biological Assay
  • Carcinogenicity Tests
  • Carcinogens / classification*
  • Carcinogens / toxicity*
  • Humans
  • Hybridization, Genetic
  • Mice
  • Mutagenicity Tests
  • Mutagens / toxicity
  • Neoplasms, Experimental / chemically induced
  • Organ Specificity
  • Polymorphism, Genetic
  • Predictive Value of Tests
  • Rats
  • Rodentia*
  • Species Specificity

Substances

  • Carcinogens
  • Mutagens