Distribution of DYZ2 repetitive sequences on the human Y chromosome

Hum Genet. 1993 Jan;90(5):572-4. doi: 10.1007/BF00217462.

Abstract

The distribution of the 2000 copies of the Y-specific repetitive family DYZ2 is controversial since previous reports have mapped these sequences to different sites of the Yqh region. In this work, we have performed non-radioactive in situ hybridization of a cloned DYZ2 fragment at higher stringency conditions on 5-aza-cytidine-enlarged Y chromosomes; the results suggest a non-uniform distribution of these sequences, which are preferentially located at the proximal and distal parts of Yqh, including the C+/Q- heterochromatin at the boundary with the euchromatic region.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Azacitidine
  • Chromosome Mapping
  • DNA / analysis
  • Genetic Techniques
  • Heterochromatin
  • Humans
  • In Situ Hybridization
  • Male
  • Multigene Family*
  • Repetitive Sequences, Nucleic Acid*
  • Y Chromosome*

Substances

  • Heterochromatin
  • DNA
  • Azacitidine