Molecular biology of somatostatin receptors

Trends Neurosci. 1993 Jan;16(1):34-8. doi: 10.1016/0166-2236(93)90050-v.


The neuropeptide somatostatin (SRIF) has diverse physiological actions in the brain and endocrine organs. A family of SRIF receptors has recently been cloned that may mediate the distinct biological effects of SRIF. These receptors have a high degree of amino acid sequence similarity among themselves, but their sequences are different from any other receptors, indicating that they represent a distinct neurotransmitter receptor subfamily. The availability of the cloned receptors will now allow for detailed structure-function analysis of SRIF receptors and will facilitate development of subtype-selective agonists and antagonists that could be useful in the treatment of central nervous system and endocrine disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Molecular Sequence Data
  • Receptors, Somatostatin / drug effects
  • Receptors, Somatostatin / metabolism*


  • Receptors, Somatostatin