Outwardly rectifying chloride channels and CF: a divorce and remarriage

J Bioenerg Biomembr. 1993 Feb;25(1):27-35. doi: 10.1007/BF00768065.


Outwardly rectifying Cl- channels were originally thought to be the central element in cystic fibrosis. The role of these channels in CF was questioned to such an extent that doubts were raised about the validity of the original experiments. Recent data reestablishes a role for outwardly rectifying Cl- channels (ORCC) in CF and suggests that the protein encoded by the CF gene, the cystic fibrosis transmembrane regulator (CFTR), can effect the regulation of more than one channel in the airway. This minireview deals with the rise, fall, and resurrection of the role of outwardly rectifying Cl- channels in CF.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Chloride Channels
  • Chlorides / metabolism
  • Cystic Fibrosis / genetics
  • Cystic Fibrosis / metabolism*
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Humans
  • Ion Channel Gating
  • Ion Channels / metabolism
  • Membrane Proteins / metabolism*
  • Protein Kinases / metabolism


  • CFTR protein, human
  • Chloride Channels
  • Chlorides
  • Ion Channels
  • Membrane Proteins
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • Protein Kinases