Agrin and the molecular choreography of synapse formation

Trends Neurosci. 1993 Feb;16(2):72-6. doi: 10.1016/0166-2236(93)90020-m.

Abstract

High concentrations of neurotransmitter receptors characterize neuromuscular junctions as well as neuron-neuron synapses in the brain and periphery. Synaptic function is critically dependent upon this marshalling of neurotransmitter receptors to the post-synaptic membrane. This review discusses agrin's role in orchestrating the molecular topography of the post-synaptic apparatus at nerve-muscle synapses and the emerging evidence suggesting a role for agrin in synaptogenesis in the brain.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Agrin
  • Animals
  • Brain Chemistry
  • Chickens / genetics
  • Extracellular Matrix Proteins / genetics
  • Extracellular Matrix Proteins / physiology*
  • Genes
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / physiology*
  • RNA Splicing
  • Rats / genetics
  • Receptor Aggregation
  • Receptors, Growth Factor*
  • Receptors, Neurotransmitter / metabolism
  • Synapses / metabolism*
  • Torpedo / genetics

Substances

  • Agrin
  • Extracellular Matrix Proteins
  • Nerve Tissue Proteins
  • Receptors, Growth Factor
  • Receptors, Neurotransmitter
  • agrin receptor