Activation of mucosal V beta 3+ T cells and tissue damage in human small intestine by the bacterial superantigen, Staphylococcus aureus enterotoxin B

Eur J Immunol. 1993 Mar;23(3):664-8. doi: 10.1002/eji.1830230314.


Staphylococcus aureus enterotoxin B (SEB) was added to explants of fetal human intestine in organ culture or administered into the lumen of fetal small intestine prior to culture. Both routes produced a massive increase in lamina propria T cells expressing V beta 3, and to a lesser extent, those expressing V beta 5 and V beta 12. SEB-activated lamina propria T cells produced interleukin-2 and interferon-gamma and T cell activation was accompanied by tissue damage, which was inhibited by FK506.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Bacterial / immunology*
  • Enterotoxins / immunology*
  • Humans
  • Intestinal Mucosa / immunology
  • Intestinal Mucosa / pathology
  • Intestine, Small / immunology*
  • Intestine, Small / pathology
  • Lymphocyte Activation / drug effects
  • Organ Culture Techniques
  • Receptors, Antigen, T-Cell, alpha-beta / immunology
  • Staphylococcus aureus / immunology*
  • T-Lymphocytes / immunology*
  • Tacrolimus / pharmacology


  • Antigens, Bacterial
  • Enterotoxins
  • Receptors, Antigen, T-Cell, alpha-beta
  • Tacrolimus