Rearrangement of band q13 on both chromosomes 12 in a periosteal chondroma

Genes Chromosomes Cancer. 1993 Feb;6(2):121-3. doi: 10.1002/gcc.2870060210.

Abstract

Cytogenetic analysis of a recurrent periosteal chondroma revealed nonreciprocal translocations of both chromosomal segments 12q13-->qter, from one chromosome 12 to 7q32 and from the homologous chromosome 12 to 16q22. The remaining parts of the two chromosomes 12 formed a dicentric chromosome. This is the second reported chondroma with a 12q13-15 rearrangement, and changes of this chromosome region consequently seem to be nonrandom occurrences in chondromas.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chondroma / genetics*
  • Chromosomes, Human, Pair 12 / ultrastructure*
  • Chromosomes, Human, Pair 16 / ultrastructure*
  • Chromosomes, Human, Pair 7 / ultrastructure
  • Femoral Neoplasms / genetics*
  • Gene Rearrangement*
  • Humans
  • Karyotyping
  • Male
  • Neoplasm Recurrence, Local / genetics
  • Translocation, Genetic*