Abstract
The product of the retinoblastoma gene (RB1) is believed to function as a negative regulator of cell growth. Recent experimental results suggest that RB1 may exert its growth-suppressing activity by regulating the transcription of a variety of growth-related genes, including FOS, MYC, and TGFBI. A series of biochemical and molecular analyses suggest that RB1 indirectly affects gene expression via cell-cycle-regulated interactions with transcription factors, such as E2F and SPI. Determination of the mechanisms regulating such protein-protein interactions and the identification of additional targets of RB1 function will provide vital insights into the role of this tumor-suppressor gene in mammalian cell proliferation.
MeSH terms
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Adenovirus E1A Proteins / metabolism
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Animals
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Base Sequence
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Consensus Sequence
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DNA-Binding Proteins
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Eye Neoplasms / genetics
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Fungal Proteins / metabolism
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Gene Expression Regulation*
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Genes, Retinoblastoma
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Genes, fos
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Genes, myc
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Humans
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Mice
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Molecular Sequence Data
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Peptide Elongation Factor 2
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Peptide Elongation Factors / metabolism
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Promoter Regions, Genetic
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Repressor Proteins / physiology
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Retinoblastoma / genetics
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Retinoblastoma Protein / physiology*
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Saccharomyces cerevisiae Proteins*
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Sp1 Transcription Factor / metabolism
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Transcription Factors*
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Transcription, Genetic*
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Transforming Growth Factor beta / genetics
Substances
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Adenovirus E1A Proteins
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DNA-Binding Proteins
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Fungal Proteins
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GAL4 protein, S cerevisiae
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Peptide Elongation Factor 2
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Peptide Elongation Factors
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Repressor Proteins
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Retinoblastoma Protein
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Saccharomyces cerevisiae Proteins
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Sp1 Transcription Factor
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Transcription Factors
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Transforming Growth Factor beta