Skn-1a and Skn-1i: two functionally distinct Oct-2-related factors expressed in epidermis

Science. 1993 Apr 2;260(5104):78-82. doi: 10.1126/science.7682011.


Two forms of a member of the POU domain family of transcriptional regulators, highly related to Oct-2, are selectively expressed in terminally differentiating epidermis and hair follicles. One form, referred to as Skn-1i, contains an amino-terminal domain that inhibits DNA binding and can inhibit transactivation by Oct-1. A second form, Skn-1a, contains an alternative amino terminus and serves to activate cytokeratin 10 (K10) gene expression. The pattern of expression of the Skn-1a/i gene products and the effect of the alternative products on the expression of other genes suggest that these factors serve regulatory functions with respect to epidermal development.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Basic-Leucine Zipper Transcription Factors
  • DNA / chemistry
  • DNA / genetics
  • DNA / metabolism
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics*
  • Epidermis / metabolism*
  • Gene Expression* / drug effects
  • Keratins / genetics
  • Leucine Zippers
  • Macromolecular Substances
  • Mice
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • Octamer Transcription Factor-2
  • Polymerase Chain Reaction
  • Repressor Proteins*
  • Sequence Homology, Amino Acid
  • Transcription Factors / chemistry
  • Transcription Factors / genetics*
  • Transcription Factors / metabolism
  • Transcription Factors / pharmacology


  • Basic-Leucine Zipper Transcription Factors
  • DNA-Binding Proteins
  • Macromolecular Substances
  • Octamer Transcription Factor-2
  • Pou2f2 protein, mouse
  • Pou2f2 protein, rat
  • Repressor Proteins
  • TEF protein, human
  • Tef protein, mouse
  • Transcription Factors
  • Keratins
  • DNA

Associated data

  • GENBANK/L23862
  • GENBANK/L23863