[A case of testicular choriocarcinoma achieving pathological complete response by "COMPE" chemotherapy, consisting of cisplatin, vincristine, methotrexate, peplomycin, and etoposide]

Hinyokika Kiyo. 1993 Feb;39(2):183-7.
[Article in Japanese]


We report a case of pure choriocarcinoma of the left testis in a 27-year-old male. He consulted a physician with left back pain in August, 1990. Intravenous pyelography (IVP) revealed left hydronephrosis. Abnormal computerized tomography (CT) revealed para-aortic lymph node swelling. The chest X-ray revealed bilateral multiple coin lesions. The genital examination revealed a left testicular nodule 8 mm in diameter. Left high inguinal orchiectomy was performed. Histopathological diagnosis was pure choriocarcinoma. After 4 courses of the PVB (cisplatin, vinblastine, bleomycin) therapy, tumor regression rate of the pulmonary metastases was 41.9%. He was transferred to our hospital on December 3, 1990 and was admitted 3 days later. "COMPE" chemotherapy, consisting of cisplatin, vincristine, methotrexate, peplomycin, and etoposide, was administered. After seven courses of "COMPE" chemotherapy, he achieved a partial response (the regression rate of the pulmonary metastases and the retroperitoneal lymph node metastasis were 78.8% and 69.1%, respectively) and the residual masses in the lungs and the retroperitoneum were removed. Necrosis and xanthogranulomatous fibrosis were found in the resected material. The patient showed no evidence of disease one year after thoracotomy.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Bleomycin / administration & dosage
  • Choriocarcinoma / complications
  • Choriocarcinoma / drug therapy*
  • Choriocarcinoma / pathology
  • Cisplatin / administration & dosage
  • Drug Administration Schedule
  • Etoposide / administration & dosage
  • Humans
  • Hydronephrosis / complications
  • Male
  • Methotrexate / administration & dosage
  • Peplomycin
  • Remission Induction
  • Testicular Neoplasms / complications
  • Testicular Neoplasms / drug therapy*
  • Testicular Neoplasms / pathology
  • Vinblastine / administration & dosage
  • Vincristine / administration & dosage


  • Bleomycin
  • Peplomycin
  • Vincristine
  • Vinblastine
  • Etoposide
  • Cisplatin
  • Methotrexate

Supplementary concepts

  • COMPE protocol
  • PVB protocol