Abstract
Familial germ cell tumours are well recognised in kinship with gonadal dysgenesis, but their occurrence in siblings with normal chromosomes is rare. We report two sisters who presented within a 4 month period with malignant ovarian germ cell tumours; one a dysgerminoma and the other a mixed tumour with marked choriocarcinomatous elements. Both children had a normal female constitutional karyotype and normal phenotype.
MeSH terms
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Bleomycin / administration & dosage
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Carboplatin / administration & dosage
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Chemotherapy, Adjuvant
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Child
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Choriocarcinoma / drug therapy
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Choriocarcinoma / genetics
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Choriocarcinoma / surgery
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Dysgerminoma / drug therapy
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Dysgerminoma / genetics*
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Dysgerminoma / surgery
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Etoposide / administration & dosage
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Female
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Humans
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Neoplasms, Germ Cell and Embryonal / drug therapy
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Neoplasms, Germ Cell and Embryonal / genetics*
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Neoplasms, Germ Cell and Embryonal / surgery
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Nuclear Family
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Ovarian Neoplasms / drug therapy
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Ovarian Neoplasms / genetics*
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Ovarian Neoplasms / surgery
Substances
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Bleomycin
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Etoposide
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Carboplatin