Epstein-Barr virus and gastric cancer: data and unanswered questions

Int J Cancer. 1993 Apr 1;53(6):898-901. doi: 10.1002/ijc.2910530605.


Sixty-five unselected cases of gastric cancer have been analysed for EBV DNA by polymerase chain reaction, in situ hybridization and immunohistochemistry for CD21 antigen expression. Four cases were found EBV-positive by PCR, while ISH yielded positive results in 3 of these cases, demonstrating EBV in the nuclei of cancerous cells. CD21 antigen was expressed in cancerous cells in all 3 ISH-positive cases. All the EBV-positive cancers of the present series were poorly to moderately differentiated adenocarcinomas with prominent lymphoid infiltration. These results are discussed also on the basis of the literature.

MeSH terms

  • Adenocarcinoma / microbiology*
  • Adult
  • Aged
  • Aged, 80 and over
  • Base Sequence
  • DNA, Viral / analysis
  • Dendritic Cells / chemistry
  • Female
  • Herpesvirus 4, Human / genetics*
  • Humans
  • Immunohistochemistry
  • In Situ Hybridization
  • Lymphoid Tissue / chemistry
  • Male
  • Microtomy
  • Middle Aged
  • Molecular Sequence Data
  • Neoplasm Staging
  • Paraffin Embedding
  • Polymerase Chain Reaction
  • Receptors, Complement 3d
  • Staining and Labeling / methods
  • Stomach Neoplasms / microbiology*


  • DNA, Viral
  • Receptors, Complement 3d