Distinct rat genes with related profiles of expression define a TIE receptor tyrosine kinase family

Oncogene. 1993 Jun;8(6):1631-7.


We have isolated rat cDNAs that encode two related receptor-like tyrosine kinases. One of these receptors, TIE-1, is the rat homolog of a recently described human receptor-like kinase termed TIE (Partanen et al., 1992). The related TIE-2 receptor has the same organization of amino acid sequence motifs characteristic of TIE-1: two immunoglobulin-like domains, three epidermal growth factor (EGF)-like domains and three fibronectin III-like repeats in the extracellular region and a short kinase insert sequence and C-terminal tail in the intracellular region. The amino acid sequences of the intracellular and extracellular regions of TIE-1 and TIE-2 are 79% and 32% identical respectively. Both tie genes are broadly expressed in embryonic, neonatal and adult tissues, accounted for largely by their coexpression in endothelial cells. The tie-2 gene is also uniquely expressed in several additional embryonic tissues, including the lens epithelium and the heart epicardium.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging / metabolism
  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Brain / metabolism*
  • Cloning, Molecular
  • DNA / genetics
  • DNA / isolation & purification
  • Embryo, Mammalian
  • Heart / embryology
  • Heart / physiology
  • Humans
  • In Situ Hybridization
  • Molecular Sequence Data
  • Multigene Family*
  • Oligodeoxyribonucleotides
  • Organ Specificity
  • Protein-Tyrosine Kinases / genetics*
  • RNA / genetics
  • RNA / isolation & purification
  • Rats
  • Receptor, TIE-1
  • Receptor, TIE-2
  • Receptors, Cell Surface / genetics*
  • Receptors, TIE
  • Restriction Mapping
  • Sequence Homology, Amino Acid


  • Oligodeoxyribonucleotides
  • Receptors, Cell Surface
  • RNA
  • DNA
  • Protein-Tyrosine Kinases
  • Receptor, TIE-1
  • Receptor, TIE-2
  • Receptors, TIE

Associated data