Arachidonic acid in cell signaling

Curr Opin Cell Biol. 1993 Apr;5(2):274-80. doi: 10.1016/0955-0674(93)90116-8.


Important advances have recently been made in our understanding of the arachidonic acid cascade. The molecular characterization of different forms of phospholipase A2 indicates that multiple pathways are involved in the release of arachidonic acid evoked by physiological or pathological stimuli. Moreover, studies on the expression of enzymes that metabolize arachidonic acid reveal the potential participation of the eicosanoids in central aspects of cell regulation, such as control of mitogenesis. Finally, cloning of the first eicosanoid receptors is a major step towards elucidating the diverse cellular functions exerted by these bioactive lipids.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arachidonic Acid / metabolism*
  • Calcium / metabolism
  • Ion Channels
  • Phospholipases A / metabolism*
  • Phospholipases A2
  • Protein Kinase C / metabolism
  • Signal Transduction*


  • Ion Channels
  • Arachidonic Acid
  • Protein Kinase C
  • Phospholipases A
  • Phospholipases A2
  • Calcium