A new polymorphic restriction site at the human atrial natriuretic peptide (hANP) gene locus

Hum Genet. 1993 Jun;91(5):509-10. doi: 10.1007/BF00217782.

Abstract

A unique two allele polymorphism for both HpaII and SmaI is described in the second intron of the human atrial natriuretic peptide gene. It should be a useful marker of this candidate gene in familial susceptibility to hypertension.

MeSH terms

  • Alleles
  • Atrial Natriuretic Factor / genetics*
  • Base Sequence
  • DNA, Single-Stranded / analysis
  • DNA-Cytosine Methylases
  • Deoxyribonuclease HpaII
  • Deoxyribonucleases, Type II Site-Specific
  • Humans
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Polymorphism, Restriction Fragment Length*

Substances

  • DNA, Single-Stranded
  • Atrial Natriuretic Factor
  • DNA modification methylase XcyI
  • DNA-Cytosine Methylases
  • Deoxyribonuclease HpaII
  • Deoxyribonucleases, Type II Site-Specific