Vascular cell adhesion molecule-1: expression in normal and diseased skin and regulation in vivo by interferon gamma

J Am Acad Dermatol. 1993 Jul;29(1):67-72. doi: 10.1016/0190-9622(93)70154-l.


Background: Vascular cell adhesion molecule-1 (VCAM-1) is an endothelial protein with adhesive properties for inflammatory cells including lymphocytes. Its role in skin disease and regulation in vivo are uncertain.

Objective: Our purpose was to determine expression of VCAM-1 in normal and inflamed skin and the effect on this of the T-cell-derived cytokine interferon gamma (IFN-gamma).

Methods: VCAM-1 was detected immunohistochemically in frozen-section biopsy specimens of inflammatory dermatoses and skin tumors. Volunteers received intradermal IFN-gamma and underwent biopsy 2 hours to 6 days later.

Results: In normal skin, VCAM-1 was present on perivascular dendritic cells and some follicular keratinocytes. In allergic contact dermatitis, atopic dermatitis, and psoriasis, VCAM-1 was variably upregulated on dermal endothelium and dendritic cells, but was most pronounced in lichen planus. IFN-gamma led to marked upregulation of endothelial and dermal dendritic cell VCAM-1.

Conclusion: VCAM-1 may be involved in the pathogenesis of various skin diseases and in vivo, IFN-gamma is a potent modulator of its expression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Adhesion Molecules / genetics*
  • Dendritic Cells / metabolism
  • Dermatitis, Allergic Contact / genetics
  • Dermatitis, Allergic Contact / metabolism
  • Dermatitis, Atopic / genetics
  • Dermatitis, Atopic / metabolism
  • Endothelium, Vascular / metabolism
  • Gene Expression Regulation*
  • Gene Expression Regulation, Neoplastic
  • Gene Expression*
  • Humans
  • Immunoenzyme Techniques
  • Interferon-gamma / pharmacology*
  • Keratinocytes / metabolism
  • Lichen Planus / genetics
  • Lichen Planus / metabolism
  • Precancerous Conditions / genetics
  • Precancerous Conditions / metabolism
  • Recombinant Proteins
  • Skin / metabolism*
  • Skin Diseases / genetics*
  • Skin Diseases / metabolism
  • Skin Neoplasms / genetics*
  • Skin Neoplasms / metabolism
  • T-Lymphocytes / metabolism
  • Up-Regulation
  • Vascular Cell Adhesion Molecule-1


  • Cell Adhesion Molecules
  • Recombinant Proteins
  • Vascular Cell Adhesion Molecule-1
  • Interferon-gamma