Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments

FEBS Lett. 1993 Jul 5;325(3):167-72. doi: 10.1016/0014-5793(93)81066-9.

Abstract

We previously reported that tau protein kinase I (TPKI) induced normal tau protein into a state of paired helical filaments (PHF); this is further confirmed here by immunoblot analysis using several antibodies. We also present the amino acid sequence of TPKI, which is identical to glycogen synthase kinase 3 beta (GSK3 beta). Moreover, we found that TPKI activity was inseparable from GSK3 activity throughout the purification procedure. These results indicate that TPKI is identical to GSK3 beta.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Cattle
  • DNA
  • Epitopes
  • Glycogen Synthase Kinase 3
  • Glycogen Synthase Kinases
  • Humans
  • Immunoblotting
  • Molecular Sequence Data
  • Protein Kinases / chemistry*
  • Protein Kinases / immunology
  • Protein Serine-Threonine Kinases / chemistry*
  • Protein Serine-Threonine Kinases / immunology
  • Rats
  • Substrate Specificity

Substances

  • Epitopes
  • DNA
  • Protein Kinases
  • Glycogen Synthase Kinases
  • Protein Serine-Threonine Kinases
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Glycogen Synthase Kinase 3
  • tau-protein kinase