Effects of gamma-interferon on collagen and histamine content in bleomycin-induced lung fibrosis in rats

Lymphokine Cytokine Res. 1993 Apr;12(2):87-91.


Recombinant rat gamma-interferon was found to inhibit collagen accumulation induced by the intratracheal administration of bleomycin in rat lungs. gamma-Interferon also elicited a reduction in histamine content in the lungs of the bleomycin-treated rats; however, this agent did not cause any obvious changes in inflammatory cell infiltration into the lung. These results suggest that gamma-interferon inhibits the development of pulmonary fibrosis by suppressing collagen synthesis and could thus be used as a therapeutic agent for preventing this condition.

MeSH terms

  • Animals
  • Bleomycin
  • Collagen / biosynthesis*
  • Fibroblasts / drug effects
  • Histamine / biosynthesis*
  • Interferon-gamma / pharmacology*
  • Lung / drug effects
  • Male
  • Organ Size
  • Pulmonary Fibrosis / chemically induced
  • Pulmonary Fibrosis / pathology
  • Pulmonary Fibrosis / prevention & control*
  • Rats
  • Rats, Inbred Lew
  • Recombinant Proteins / pharmacology


  • Recombinant Proteins
  • Bleomycin
  • Histamine
  • Interferon-gamma
  • Collagen