Tau-2 immunoreactivity of corpora amylacea in the human retina and optic nerve

Invest Ophthalmol Vis Sci. 1993 Jul;34(8):2600-3.

Abstract

Purpose: To characterize the constituents of corpora amylacea in the human retina and optic nerve.

Methods: Immunohistochemistry was performed on sections of retina, optic nerve, and brain tissue using antibodies against tau 1, tau-2, and amyloid precursor protein.

Results: Consistent anti-tau-2 immunoreactivity was noted in the corpora amylacea in the retina, optic nerve, and brain tissue, albeit with variations in pattern and intensity of staining. No immunoreactivity was observed with antibodies anti-tau 1 and anti-amyloid precursor protein.

Conclusion: Our findings suggest the accumulation of possibly abnormal tau-2 within the corpora amylacea, which may be either astrocytic or axonal in origin.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology
  • Amyloid beta-Protein Precursor
  • Humans
  • Immunoenzyme Techniques
  • Immunohistochemistry
  • Inclusion Bodies / metabolism
  • Inclusion Bodies / pathology*
  • Microtubule-Associated Proteins
  • Middle Aged
  • Neurofibrillary Tangles / metabolism
  • Neurofibrillary Tangles / pathology
  • Optic Nerve / metabolism
  • Optic Nerve / pathology*
  • Retina / metabolism
  • Retina / pathology*
  • Staining and Labeling

Substances

  • Amyloid beta-Protein Precursor
  • Microtubule-Associated Proteins