Metalloenzymes, structural motifs, and inorganic models

Science. 1993 Aug 6;261(5122):701-8. doi: 10.1126/science.7688141.


Metalloenzymes effect a variety of important chemical transformations, often involving small molecule substrates or products such as molecular oxygen, hydrogen, nitrogen, and water. A diverse array of ions or metal clusters is observed at the active-site cores, but living systems use basic recurring structures that have been modified or tuned for specific purposes. Inorganic chemists are actively involved in the elucidation of the structure, spectroscopy, and mechanism of action of these biological catalysts, in part through a synthetic modeling approach involving biomimetic studies.

Publication types

  • Comment
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Oxidoreductases / chemistry
  • Amino Acid Oxidoreductases / metabolism
  • Binding Sites
  • Electron Transport
  • Enzymes / chemistry*
  • Enzymes / metabolism
  • Hydrolysis
  • Iron-Sulfur Proteins / chemistry
  • Iron-Sulfur Proteins / metabolism
  • Metalloproteins / chemistry*
  • Metalloproteins / metabolism
  • Models, Chemical*
  • Models, Molecular
  • Nitric Oxide / metabolism
  • Nitric Oxide Synthase
  • Oxidation-Reduction
  • Peptides / metabolism


  • Enzymes
  • Iron-Sulfur Proteins
  • Metalloproteins
  • Peptides
  • Nitric Oxide
  • Nitric Oxide Synthase
  • Amino Acid Oxidoreductases