The CD19-CR2-TAPA-1 complex, CD45 and signaling by the antigen receptor of B lymphocytes

Curr Opin Immunol. 1993 Jun;5(3):341-8. doi: 10.1016/0952-7915(93)90051-s.

Abstract

A paradigm describing the response of T lymphocytes to antigen holds that signals from antigen receptors must be modulated by non-antigen-specific, accessory membrane proteins for an appropriate cellular response to occur, such as differentiation, activation and tolerance. Recent studies suggest that this paradigm applies also to B lymphocytes. Signaling through membrane IgM in these cells requires CD45, a phosphotyrosine phosphatase, and is amplified by a complex containing CD19, complement receptor 2 (CD21), and TAPA-1, which recruits the intracellular enzyme, phosphatidylinositol 3-kinase.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, CD / physiology*
  • Antigens, CD19
  • Antigens, Differentiation, B-Lymphocyte / physiology*
  • Antigens, Surface / physiology*
  • B-Lymphocytes / immunology*
  • Guinea Pigs
  • Humans
  • Immunoglobulin M / immunology
  • Leukocyte Common Antigens / physiology*
  • Ligands
  • Lymphocyte Activation / physiology*
  • Macromolecular Substances
  • Membrane Proteins*
  • Mice
  • Models, Biological
  • Multigene Family
  • Phosphorylation
  • Protein Processing, Post-Translational
  • Protein-Tyrosine Kinases / physiology
  • Receptors, Antigen, B-Cell / physiology*
  • Receptors, Complement 3d / physiology*
  • Signal Transduction / physiology*
  • Tetraspanin 28

Substances

  • Antigens, CD
  • Antigens, CD19
  • Antigens, Differentiation, B-Lymphocyte
  • Antigens, Surface
  • CD81 protein, human
  • Cd81 protein, mouse
  • Immunoglobulin M
  • Ligands
  • Macromolecular Substances
  • Membrane Proteins
  • Receptors, Antigen, B-Cell
  • Receptors, Complement 3d
  • Tetraspanin 28
  • Protein-Tyrosine Kinases
  • Leukocyte Common Antigens