Abstract
Maximal expression of the interleukin-2 gene in T cells depends on biochemical signals in addition to those transduced by the T cell antigen receptor. Recent work indicates that the T-cell specific molecule CD28 transduces a 'costimulatory' signal when it binds its ligand, the B7 molecule, on the surface of an antigen-presenting cell. Results from experiments performed during the past year have raised the exciting possibility that immune responses can be either inhibited or augmented by manipulation of the CD28-B7 interaction.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antigen-Presenting Cells / immunology*
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Antigens, CD / physiology*
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Antigens, Differentiation, T-Lymphocyte / physiology*
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Antigens, Surface
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B7-1 Antigen
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CD28 Antigens
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Calcium / physiology
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Cell Division
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Humans
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Immune Tolerance
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Interleukin-2 / biosynthesis*
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Ligands
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Lymphocyte Activation / physiology*
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Macromolecular Substances
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Mice
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Receptors, Antigen, T-Cell / immunology*
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Signal Transduction / physiology*
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T-Lymphocyte Subsets / immunology*
Substances
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Antigens, CD
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Antigens, Differentiation, T-Lymphocyte
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Antigens, Surface
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B7-1 Antigen
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CD28 Antigens
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Interleukin-2
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Ligands
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Macromolecular Substances
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Receptors, Antigen, T-Cell
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Calcium