Molecules involved in T-cell costimulation

Curr Opin Immunol. 1993 Jun;5(3):361-7. doi: 10.1016/0952-7915(93)90054-v.


Maximal expression of the interleukin-2 gene in T cells depends on biochemical signals in addition to those transduced by the T cell antigen receptor. Recent work indicates that the T-cell specific molecule CD28 transduces a 'costimulatory' signal when it binds its ligand, the B7 molecule, on the surface of an antigen-presenting cell. Results from experiments performed during the past year have raised the exciting possibility that immune responses can be either inhibited or augmented by manipulation of the CD28-B7 interaction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology*
  • Antigens, CD / physiology*
  • Antigens, Differentiation, T-Lymphocyte / physiology*
  • Antigens, Surface
  • B7-1 Antigen
  • CD28 Antigens
  • Calcium / physiology
  • Cell Division
  • Humans
  • Immune Tolerance
  • Interleukin-2 / biosynthesis*
  • Ligands
  • Lymphocyte Activation / physiology*
  • Macromolecular Substances
  • Mice
  • Receptors, Antigen, T-Cell / immunology*
  • Signal Transduction / physiology*
  • T-Lymphocyte Subsets / immunology*


  • Antigens, CD
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Surface
  • B7-1 Antigen
  • CD28 Antigens
  • Interleukin-2
  • Ligands
  • Macromolecular Substances
  • Receptors, Antigen, T-Cell
  • Calcium