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Clinical Trial
, 29 (3), 438-42

A Double-Blind Evaluation of Topical Capsaicin in Pruritic Psoriasis

Clinical Trial

A Double-Blind Evaluation of Topical Capsaicin in Pruritic Psoriasis

C N Ellis et al. J Am Acad Dermatol.


Background: Substance P, an undecapeptide neurotransmitter, has been implicated in the pathophysiology of psoriasis and pruritus.

Objective: Safety and efficacy of topical capsaicin, a potent substance P depletor, were evaluated in patients with pruritic psoriasis.

Methods: Patients applied capsaicin 0.025% cream (n = 98) or vehicle (n = 99) four times a day for 6 weeks in this double-blind study. Efficacy was based on a physician's global evaluation and a combined psoriasis severity score including scaling, thickness, erythema, and pruritus.

Results: Capsaicin-treated patients demonstrated significantly greater improvement in global evaluation (p = 0.024 after 4 weeks and p = 0.030 after 6 weeks) and in pruritus relief (p = 0.002 and p = 0.060, respectively), as well as a significantly greater reduction in combined psoriasis severity scores (p = 0.030 and p = 0.036, respectively). The most frequently reported side effect in both treatment groups was a transient burning sensation at application sites.

Conclusion: Topically applied capsaicin effectively treats pruritic psoriasis, a finding that supports a role for substance P in this disorder.

Comment in

  • Topical capsaicin in pruritic psoriasis.
    Arnold WP, van de Kerkhof PC. Arnold WP, et al. J Am Acad Dermatol. 1994 Jul;31(1):135. doi: 10.1016/s0190-9622(09)80256-9. J Am Acad Dermatol. 1994. PMID: 8021363 No abstract available.

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