Caffeic acid phenethyl ester as a lipoxygenase inhibitor with antioxidant properties

FEBS Lett. 1993 Aug 23;329(1-2):21-4. doi: 10.1016/0014-5793(93)80184-v.

Abstract

Caffeic acid phenethyl ester, an active component of propolis extract, inhibits 5-lipoxygenase in the micromolar concentration range. The inhibition is of an uncompetitive type, i.e. the inhibitor binds to the enzyme-substrate complex but not to the free enzyme. Caffeic acid phenethyl ester also exhibits antioxidant properties. At a concentration of 10 microM, it completely blocks production of reactive oxygen species in human neutrophils and the xanthine/xanthine oxidase system.

MeSH terms

  • Antioxidants / pharmacology*
  • Caffeic Acids / pharmacology*
  • Hordeum / enzymology
  • Humans
  • Kinetics
  • Linoleic Acid
  • Linoleic Acids / metabolism
  • Lipoxygenase Inhibitors / pharmacology*
  • Luminescent Measurements
  • Neutrophils / drug effects
  • Neutrophils / metabolism
  • Oxidation-Reduction
  • Phenylethyl Alcohol / analogs & derivatives*
  • Phenylethyl Alcohol / pharmacology
  • Reactive Oxygen Species / metabolism
  • Xanthine
  • Xanthine Oxidase / metabolism
  • Xanthines / metabolism

Substances

  • Antioxidants
  • Caffeic Acids
  • Linoleic Acids
  • Lipoxygenase Inhibitors
  • Reactive Oxygen Species
  • Xanthines
  • Xanthine
  • Linoleic Acid
  • Xanthine Oxidase
  • caffeic acid phenethyl ester
  • Phenylethyl Alcohol
  • caffeic acid