Strong association between HLA-DRW2 and antibody-mediated Goodpasture's syndrome

Lancet. 1978 May 6;1(8071):966-8. doi: 10.1016/s0140-6736(78)90252-0.

Abstract

In a study of HLA types in Caucasian patients with nephritis due to antibodies to glomerular basement membrane, antigen frequencies at A, B, or CW loci were normal. However, 15 out of 17 (88%) patients to whom DRW types were definitely assigned had HLA-DRW2 compared with 32 out of 100 Caucasian blood-donors. This difference is highly significant.

MeSH terms

  • Anti-Glomerular Basement Membrane Disease / etiology*
  • Anti-Glomerular Basement Membrane Disease / immunology
  • Autoantibodies / isolation & purification
  • Autoantigens
  • Autoimmune Diseases*
  • Basement Membrane / immunology
  • Cross Reactions
  • HLA Antigens* / isolation & purification
  • Histocompatibility Testing
  • Humans
  • Kidney Glomerulus / immunology

Substances

  • Autoantibodies
  • Autoantigens
  • HLA Antigens