Stereospecific antagonism by (+)-alpha-methyl-4-carboxyphenylglycine (MCPG) of (1S,3R)-ACPD-induced effects in neonatal rat motoneurones and rat thalamic neurones

Neuropharmacology. 1993 Jul;32(7):725-7. doi: 10.1016/0028-3908(93)90088-k.

Abstract

The (+)-enantiomer of alpha-methyl-4-carboxyphenylglycine (MCPG) stereoslectively antagonized the depolarization of neonatal rat motoneurones and the excitation of rat thalamic neurons induced by the specific metabotropic glutamate receptor agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate (ACPD). (+)-MCPG preferentially reduced (1S,3R)-ACPD-induced responses relative to responses induced by (S)-alpha-amino-3-hydorxy-5-methylisoxazole-4-propionic acid (AMPA) and N-methyl-D-aspartate (NMDA).

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn / physiology*
  • Benzoates / pharmacology*
  • Cycloleucine / analogs & derivatives*
  • Cycloleucine / antagonists & inhibitors
  • Cycloleucine / pharmacology
  • Excitatory Amino Acid Antagonists*
  • Glycine / analogs & derivatives*
  • Glycine / pharmacology
  • Ibotenic Acid / analogs & derivatives
  • Ibotenic Acid / pharmacology
  • Motor Neurons / drug effects*
  • N-Methylaspartate / pharmacology
  • Neuromuscular Depolarizing Agents / pharmacology
  • Neurons / drug effects*
  • Neurotoxins / antagonists & inhibitors*
  • Neurotoxins / pharmacology
  • Rats
  • Spinal Cord / cytology
  • Spinal Cord / drug effects
  • Stereoisomerism
  • Thalamus / cytology*
  • Thalamus / drug effects
  • alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid

Substances

  • Benzoates
  • Excitatory Amino Acid Antagonists
  • Neuromuscular Depolarizing Agents
  • Neurotoxins
  • Cycloleucine
  • 1-amino-1,3-dicarboxycyclopentane
  • alpha-methyl-4-carboxyphenylglycine
  • Ibotenic Acid
  • N-Methylaspartate
  • alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
  • Glycine