Hepatitis C virus antibody in multiply transfused Chinese with thalassaemia major

Bone Marrow Transplant. 1993;12 Suppl 1:26-8.

Abstract

Thirty-four of 99 multiply transfused Chinese (49 females, 50 males) with thalassaemia major were positive for antibody to hepatitis C virus. There was no sex predominance in seropositivity with 18 females and 16 males positive. The mean (+/- SD) age and units of blood transfused were significantly higher in the seropositive patients (167 +/- 48 months, 206 +/- 82 units respectively) than the seronegative patients (113 +/- 56 months, 124 +/- 80 units respectively). The seropositive patients had higher mean (+/- SD) serum alanine aminotransferase, aspartate aminotransferase and ferritin concentrations (91 +/- 82 IU/L, 67 +/- 38 IU/L, 4797 +/- 2522 ng/ml respectively) than the seronegative patients (38 +/- 29 IU/L, 48 +/- 28 IU/L, 3620 +/- 2140 ng/ml respectively). Serum ferritin had an independent and significant effect on serum alanine aminotransferase in addition to that of seropositivity to hepatitis C virus.

MeSH terms

  • Alanine Transaminase / blood
  • Aspartate Aminotransferases / blood
  • Biomarkers / blood
  • Child
  • Child, Preschool
  • China
  • Female
  • Ferritins / blood
  • Hepacivirus / immunology*
  • Hepatitis Antibodies / blood*
  • Hepatitis C / blood
  • Hepatitis C / complications*
  • Hepatitis C / epidemiology
  • Hepatitis C / transmission
  • Hepatitis C Antibodies
  • Humans
  • Infant
  • Male
  • Prevalence
  • Transfusion Reaction
  • beta-Thalassemia / complications*
  • beta-Thalassemia / therapy

Substances

  • Biomarkers
  • Hepatitis Antibodies
  • Hepatitis C Antibodies
  • Ferritins
  • Aspartate Aminotransferases
  • Alanine Transaminase