Nitric oxide synthesis and action in an invertebrate brain

Brain Res. 1993 Aug 13;619(1-2):344-6. doi: 10.1016/0006-8993(93)91632-3.


Nitric oxide (NO) is synthesized in mammalian neurons by Ca2+/calmodulin activated NO synthase and functions as a signalling molecule by activating soluble guanylyl cyclases in target cells. We demonstrate here that both NO synthase and NO-activated guanylyl cyclase are present in the brain of the locust Schistocerca gregaria. Our observations indicate, for the first time, that the NO-cyclic GMP signalling pathway exists in invertebrate nervous systems.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Oxidoreductases / metabolism*
  • Animals
  • Brain / metabolism*
  • Cyclic AMP / metabolism
  • Cyclic GMP / metabolism
  • Grasshoppers / metabolism*
  • Kinetics
  • Neurons / metabolism
  • Nitric Oxide / metabolism*
  • Nitric Oxide Synthase
  • Signal Transduction


  • Nitric Oxide
  • Cyclic AMP
  • Nitric Oxide Synthase
  • Amino Acid Oxidoreductases
  • Cyclic GMP