CD44 splice variants: metastases meet lymphocytes

Immunol Today. 1993 Aug;14(8):395-9. doi: 10.1016/0167-5699(93)90141-7.


Recent discoveries of surface proteins involved in tumor metastasis formation have revived an old hypothesis that tumor cells may acquire, and use for their metastatic spreading, properties which lymphoid cells had developed to defend the organism against foreign antigens. Splice variants of CD44 and integrins are expressed on metastasizing tumor cells and also on leukocytes at defined stages of their differentiation. Expression and function appear to be essential not only for the generation of an immune response but also for the establishment of metastatic tumor colonies.

Publication types

  • Review

MeSH terms

  • Alternative Splicing*
  • Animals
  • Exons / immunology
  • Humans
  • Hyaluronan Receptors
  • Integrins / immunology
  • Lymphocyte Activation
  • Mice
  • Neoplasm Metastasis / immunology*
  • Neoplasms / immunology
  • Neoplasms / pathology*
  • Receptors, Lymphocyte Homing / genetics*
  • Receptors, Lymphocyte Homing / immunology*
  • T-Lymphocytes / immunology*


  • Hyaluronan Receptors
  • Integrins
  • Receptors, Lymphocyte Homing