Sweet's syndrome associated with myelodysplasia: possible role of cytokines in the pathogenesis of the disease

Br J Haematol. 1993 Jun;84(2):356-8. doi: 10.1111/j.1365-2141.1993.tb03083.x.


The clinical course of a 56-year-old female patient with Sweet's syndrome (SS) preceded by a myelodysplastic syndrome (MDS) is described. During the acute phase of the disease with high remittent fever, painful skin lesions and maximal leucocytosis IL-6 and G-CSF serum levels were extremely high, while TNF-alpha was only slightly elevated and gamma-interferon and IL1-beta were not increased. On clinical improvement IL-6 serum levels rapidly fell, whereas G-CSF values already slightly elevated before the manifestation of the disease slowly declined. High G-CSF levels triggered by a yet unknown factor could explain the leucocytosis, neutrophilic dermatosis and skin lesions in SS, while IL-6 probably induced the associated clinical symptoms of fever and pain.

Publication types

  • Case Reports

MeSH terms

  • Cytokines / analysis*
  • Female
  • Granulocyte Colony-Stimulating Factor / analysis
  • Humans
  • Interleukin-6 / analysis
  • Middle Aged
  • Myelodysplastic Syndromes / complications*
  • Myelodysplastic Syndromes / immunology
  • Sweet Syndrome / etiology*
  • Sweet Syndrome / immunology


  • Cytokines
  • Interleukin-6
  • Granulocyte Colony-Stimulating Factor