Tenascin staining positivity and the survival of patients with invasive breast carcinoma

J Surg Res. 1993 Sep;55(3):295-7. doi: 10.1006/jsre.1993.1143.

Abstract

Tenascin immunohistochemical staining was investigated in 82 patients with primary invasive breast carcinoma followed for at least 5 years after surgery; the staining was analyzed in relation to clinicopathological factors. An intense tenascin staining pattern was noted in 59 patients (72%), but no definite correlation was found between tenascin positivity and clinical stage, lymph node metastasis, or estrogen receptor status. However, tenascin-positive patients had a significantly better prognosis than tenascin-negative patients. Tenascin staining may therefore be a useful marker for predicting the survival of breast cancer patients.

MeSH terms

  • Breast Neoplasms / chemistry*
  • Breast Neoplasms / mortality*
  • Breast Neoplasms / pathology
  • Cell Adhesion Molecules, Neuronal / analysis*
  • Extracellular Matrix Proteins / analysis*
  • Female
  • Humans
  • Immunohistochemistry
  • Lymphatic Metastasis
  • Middle Aged
  • Neoplasm Staging
  • Prognosis
  • Receptors, Estrogen / analysis
  • Survival Rate
  • Tenascin

Substances

  • Cell Adhesion Molecules, Neuronal
  • Extracellular Matrix Proteins
  • Receptors, Estrogen
  • Tenascin