Hepatocyte paraffin 1: a monoclonal antibody that reacts with hepatocytes and can be used for differential diagnosis of hepatic tumors

Am J Pathol. 1993 Oct;143(4):1050-4.


Hepatocyte paraffin 1 is a monoclonal antibody that has been developed specifically to react with hepatocytes in routine formalin-fixed and paraffin-embedded surgical pathology tissues. It results in a distinct, granular cytoplasmic staining of hepatocytes but fails to react with bile ducts and nonparenchymal liver cells. The antibody decorates a majority of hepatocellular carcinomas, including fibrolamellar variants. It fails to react with a wide variety of other adult malignancies, with the exception of focal staining in a few gastrointestinal malignancies, including a subpopulation of gastric carcinomas.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Animals
  • Antibodies, Monoclonal*
  • Carcinoma, Hepatocellular / pathology*
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Liver / immunology*
  • Liver / pathology*
  • Liver Neoplasms / pathology*
  • Mice
  • Mice, Inbred BALB C
  • Retrospective Studies
  • Staining and Labeling


  • Antibodies, Monoclonal