T helper 1 (Th1) functional phenotype of human myelin basic protein-specific T lymphocytes

Autoimmunity. 1993;15(2):137-43. doi: 10.3109/08916939309043888.


Multiple sclerosis (MS) is widely accepted as an autoimmune disease with myelin basic protein (MBP) a candidate autoantigen. In the current report, human T cell lines specific for an immunodominant region of MBP were shown to have a functional phenotype similar to T helper 1 (Th1) inflammatory cells of the mouse on the basis of their antigen-specific cytotoxic activity and production of interferon-gamma and lymphotoxin/tumor necrosis factor-alpha, but not interleukin-4. In experimental allergic encephalomyelitis (EAE), a proposed animal model for MS, MBP-specific T cell lines which mediate disease are of the Th1 subtype. Thus, MBP-specific T cells in humans exist which are phenotypically similar to MBP-specific encephalitogenic T cells in murine EAE.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amino Acid Sequence
  • Cell Line
  • Female
  • Humans
  • Interferon-gamma / biosynthesis
  • Interleukin-4 / physiology
  • Lymphotoxin-alpha / biosynthesis
  • Male
  • Molecular Sequence Data
  • Myelin Basic Protein / immunology*
  • Phenotype
  • T-Lymphocytes, Helper-Inducer / physiology*
  • Tumor Necrosis Factor-alpha / biosynthesis


  • Lymphotoxin-alpha
  • Myelin Basic Protein
  • Tumor Necrosis Factor-alpha
  • Interleukin-4
  • Interferon-gamma