Cyclosporin A, FK506 and rapamycin: more than just immunosuppression

Trends Biochem Sci. 1993 Sep;18(9):334-8. doi: 10.1016/0968-0004(93)90069-y.

Abstract

The mechanisms of action of the immunosuppressive drugs cyclosporin A (CsA), FK506 and rapamycin are strikingly conserved from yeast to human T cells. Recent results obtained with yeast corroborate calcineurin as the target of CsA-cyclophilin and FK506-FKBP complexes, and reveal a phosphatidylinositol 3-kinase homologue as the target of the rapamycin-FKBP complex.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Isomerases / metabolism
  • Amino Acid Sequence
  • Calcineurin
  • Calmodulin-Binding Proteins / metabolism
  • Carrier Proteins / metabolism
  • Consensus Sequence
  • Cyclosporine / pharmacology*
  • Immunosuppressive Agents / pharmacology*
  • Molecular Sequence Data
  • Peptidylprolyl Isomerase
  • Phosphatidylinositol 3-Kinases
  • Phosphoprotein Phosphatases / metabolism
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism
  • Polyenes / pharmacology*
  • Saccharomyces cerevisiae / drug effects
  • Signal Transduction / drug effects
  • Sirolimus
  • Tacrolimus / pharmacology*

Substances

  • Calmodulin-Binding Proteins
  • Carrier Proteins
  • Immunosuppressive Agents
  • Polyenes
  • Cyclosporine
  • Phosphatidylinositol 3-Kinases
  • Phosphotransferases (Alcohol Group Acceptor)
  • Calcineurin
  • Phosphoprotein Phosphatases
  • Amino Acid Isomerases
  • Peptidylprolyl Isomerase
  • Sirolimus
  • Tacrolimus