Recombinant cytokines and pulmonary host defense

Am J Med Sci. 1993 Nov;306(5):330-5. doi: 10.1097/00000441-199311000-00012.


The recent discovery of several cytokines and their purification using recombinant DNA technology has uncovered their role as critical factors in pulmonary host defense. The importance of tumor necrosis factor, interferon-gamma, and granulocyte-colony stimulating factor in lung infections was first elucidated in animal models and has been confirmed with neutralization studies. This article reviews these three cytokines, their recent use in human subjects, and their potential use in the future.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Granulocyte Colony-Stimulating Factor / immunology*
  • Humans
  • Immunity, Innate
  • Interferon-gamma / immunology*
  • Interferon-gamma / therapeutic use
  • Lung / immunology*
  • Pneumonia / immunology
  • Pneumonia / therapy
  • Receptors, Granulocyte Colony-Stimulating Factor
  • Recombinant Proteins / immunology
  • Recombinant Proteins / therapeutic use
  • Tumor Necrosis Factor-alpha / immunology*
  • Tumor Necrosis Factor-alpha / therapeutic use


  • Receptors, Granulocyte Colony-Stimulating Factor
  • Recombinant Proteins
  • Tumor Necrosis Factor-alpha
  • Granulocyte Colony-Stimulating Factor
  • Interferon-gamma