Abstract
A 64-year-old male suffered from splenomegaly without lymphadenopathy. His WBC count on admission was 6.1 x 10(9)/l with 55% abnormal lymphocytes. No monoclonal gammopathy was detected. Abnormal cells shown in films usually had relatively abundant cytoplasm with serrated edges. Under phase-contrast microscopy, the cells displayed short, needle-like processes. The immunophenotype of peripheral blood mononuclear cells were CD19+, CD20+, CD11c+, FMC7+, CD5+, CD10-, CD25- and SIg+. The spleen histology showed a distinctive pattern of white pulp infiltration by abnormal lymphocytes with features of plasma cell differentiation. These findings were compatible with the features of splenic lymphoma with villous lymphocytes.
MeSH terms
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Antigens, CD / analysis*
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B-Lymphocytes / chemistry
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B-Lymphocytes / pathology*
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CD11 Antigens
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CD5 Antigens
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Diagnosis, Differential
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Humans
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Immunophenotyping
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Leukemia, Hairy Cell / diagnosis
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Lymphoma, B-Cell / classification
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Lymphoma, B-Cell / diagnosis
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Lymphoma, B-Cell / pathology*
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Lymphoma, B-Cell / surgery
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Lymphoma, Non-Hodgkin / classification
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Lymphoma, Non-Hodgkin / diagnosis
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Lymphoma, Non-Hodgkin / pathology*
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Lymphoma, Non-Hodgkin / surgery
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Male
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Middle Aged
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Neoplastic Stem Cells / chemistry
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Neoplastic Stem Cells / pathology*
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Splenectomy
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Splenic Neoplasms / classification
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Splenic Neoplasms / diagnosis
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Splenic Neoplasms / pathology*
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Splenic Neoplasms / surgery
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Splenomegaly / etiology
Substances
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Antigens, CD
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CD11 Antigens
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CD5 Antigens