PA-I and PA-II lectin interactions with the ABO(H) and P blood group glycosphingolipid antigens may contribute to the broad spectrum adherence of Pseudomonas aeruginosa to human tissues in secondary infections

Glycoconj J. 1994 Oct;11(5):414-7. doi: 10.1007/BF00731276.

Abstract

Pseudomonas aeruginosa may cause serious infections in most human tissues/organs. Its adherence to them is mediated by a battery of adhesins including the PA-I and PA-II lectins, which are produced in this bacterium in high quantities. PA-I binds to the D-galactose of the erythrocyte glycosphingolipids exhibiting highest affinities for B and Pk (followed by P1) antigens, while PA-II preferentially binds to the L-fucose of H, A and B antigens. Intact P. aeruginosa cells also exhibit a clear Pk and P1 over p preference. Such affinities for the most common human ABH and P system antigens may underlie the widespread tissue infectivity and pathogenicity of this bacterium.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • ABO Blood-Group System / metabolism*
  • Adhesins, Bacterial*
  • Adult
  • Antigens / metabolism
  • Bacterial Adhesion
  • Bacterial Proteins / metabolism*
  • Carbohydrate Sequence
  • Glycosphingolipids / metabolism*
  • Humans
  • In Vitro Techniques
  • Lectins*
  • Molecular Sequence Data
  • P Blood-Group System / metabolism*
  • Pseudomonas Infections / metabolism
  • Pseudomonas Infections / microbiology
  • Pseudomonas Infections / prevention & control
  • Pseudomonas aeruginosa / metabolism*

Substances

  • ABO Blood-Group System
  • Adhesins, Bacterial
  • Antigens
  • Bacterial Proteins
  • Glycosphingolipids
  • Lectins
  • P Blood-Group System
  • adhesin, Pseudomonas