The simultaneous occurrence of variant hairy cell leukemia and chronic-phase chronic myelogenous leukemia. A case report

Cancer. 1995 Apr 15;75(8):2089-92. doi: 10.1002/1097-0142(19950415)75:8<2089::aid-cncr2820750810>;2-p.


Background: Coexistence of second malignancies in patients with hairy cell leukemia is not uncommon. Most second malignancies are solid tumors or other lymphoproliferative proliferative disorders. In this study, a case of a tartrate-resistant acid phosphatase (TRAP)-positive hairy cell leukemia variant with the subsequent development of Philadelphia chromosome-positive chronic myelogenous leukemia (CML) is reported.

Methods: Routine morphology was performed on the peripheral blood, bone marrow and spleen. Peripheral smears were stained for TRAP. Peripheral blood was studied by two-color flow cytometry for a panel of lymphocytic markers including CD11, CD25, and CD103. Cytogenetic studies were performed on a bone marrow aspirate.

Results: A unique case of a hairy cell leukemia variant and CML in a patient who responded to the new purine analog 2-chlorodeoxyadenosine (2-CdA) is presented.

Conclusions: The first case of concurrent hairy cell leukemia with CML is reported.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cladribine / therapeutic use
  • Humans
  • Leukemia, Hairy Cell / pathology*
  • Leukemia, Hairy Cell / therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy
  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive / pathology*
  • Leukemia, Myeloid, Chronic-Phase / drug therapy
  • Leukemia, Myeloid, Chronic-Phase / pathology*
  • Male
  • Neoplasms, Second Primary / drug therapy
  • Neoplasms, Second Primary / pathology*
  • Splenectomy


  • Cladribine