Myoclonus in Alzheimer disease. A confusing sign

Arch Neurol. 1976 Apr;33(4):278-80. doi: 10.1001/archneur.1976.00500040062010.


Myoclonus in association with dementia of later adult life has been considered almost pathognomonic of Creutzfeldt-Jakob disease. However, myoclonus may also be seen with Alzheimer disease, and when the myoclonus occurs as an early manifestation of Alzheimer disease, distinction from Creutzfeldt-Jakob disease may prove difficult.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Alzheimer Disease / complications*
  • Alzheimer Disease / diagnosis
  • Alzheimer Disease / pathology
  • Creutzfeldt-Jakob Syndrome / diagnosis
  • Dementia / complications*
  • Diagnosis, Differential
  • Hippocampus / pathology
  • Humans
  • Male
  • Myoclonus / etiology*
  • Neurofibrils / pathology