Trichokonin VI, a new Ca2+ channel agonist in bullfrog cardiac myocytes

Q Huang; Y Tezuka; T Kikuchi; Y Momose

doi:10.1016/0014-2999(94)90290-9

Trichokonin VI, a new Ca2+ channel agonist in bullfrog cardiac myocytes

Eur J Pharmacol. 1994 Dec 12;271(1):R5-6. doi: 10.1016/0014-2999(94)90290-9.

Authors

Q Huang¹, Y Tezuka, T Kikuchi, Y Momose

Affiliation

¹ Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, Japan.

PMID: 7698190
DOI: 10.1016/0014-2999(94)90290-9

Abstract

The effects of trichokonin VI (= gliodeliquescin A), a peptaibol isolated from the culture broth of Trichoderma koningii Oudemans, on L-type Ca2+ channel currents in single bullfrog atrial cells were investigated. Our results showed that trichokonin VI is a new potent agonist of L-type Ca2+ channels in cardiac membranes.

MeSH terms

Alamethicin / analogs & derivatives*
Alamethicin / pharmacology
Amino Acid Sequence
Animals
Calcium Channel Agonists / pharmacology*
Calcium Channels / drug effects
Calcium Channels / metabolism
Heart / drug effects*
In Vitro Techniques
Molecular Sequence Data
Myocardium / cytology
Myocardium / metabolism*
Patch-Clamp Techniques
Rana catesbeiana

Substances

Calcium Channel Agonists
Calcium Channels
Alamethicin
trichokonin VI