Blockade of feeding inhibition by neuromedin B using a selective receptor antagonist

Eur J Pharmacol. 1994 Dec 12;271(1):R7-9. doi: 10.1016/0014-2999(94)90291-7.


The ability of a selective neuromedin B receptor antagonist, D-Nal-cyclo[Cys-Tyr-D-Trp-Orn-Val-Cys]-Nal-NH2 (BIM-23127), to block suppression of food intake produced by the mammalian bombesin-like peptides neuromedin B and neuromedin C was examined. BIM-23127 completely blocked suppression of intake produced by neuromedin B but not by neuromedin C. These results suggest an independent role for neuromedin B receptors in suppression of food intake by bombesin-like peptides and demonstrate the utility of this group of antagonists for in vivo experiments.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Bombesin / metabolism
  • Eating / drug effects*
  • Glucose / metabolism
  • Male
  • Molecular Sequence Data
  • Neurokinin B / analogs & derivatives*
  • Neurokinin B / antagonists & inhibitors
  • Neurokinin B / pharmacology
  • Peptide Fragments / metabolism
  • Peptides, Cyclic / pharmacology*
  • Rats
  • Rats, Sprague-Dawley


  • BIM 23127
  • Peptide Fragments
  • Peptides, Cyclic
  • neuromedin C
  • Neurokinin B
  • neuromedin B
  • Glucose
  • Bombesin