Prognosis of patients with nonmalignant chronic intestinal failure receiving long-term home parenteral nutrition

Gastroenterology. 1995 Apr;108(4):1005-10. doi: 10.1016/0016-5085(95)90196-5.

Abstract

Background/aims: Long-term survival of patients with intestinal failure requiring home parenteral nutrition (HPN) has been only partly shown. Therefore, we described the survival of these patients and explored prognosis factors.

Methods: Two hundred seventeen noncancer non-acquired immunodeficiency syndrome adult patients presenting with chronic intestinal failure enrolled from January 1980 to December 1989 in approved HPN programs in Belgium and France; prognosis factors of survival were explored using multivariate analysis. Data were updated in March 1991; not one of the patients was lost to follow-up.

Results: Seventy-three patients died during the survey, and the mortality rate related to HPN complications accounted for 11% of deaths. Probabilities of survival at 1, 3, and 5 years were 91%, 70%, and 62%, respectively. Three independent variables were associated with a decreased risk of death: age of patients younger than 40 years, start of HPN after 1987, and absence of chronic intestinal obstruction. In patients younger than 60 years of age included after 1983 with a very short bowel, who could represent suitable candidates for small bowel transplantation, the 2-year survival rate was 90%, a prognosis that compared favorably with recent reports of survival after small bowel transplantation.

Conclusions: HPN prognosis compares favorably with recent reports of survival after small bowel transplantation.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Chronic Disease
  • Female
  • Humans
  • Intestinal Diseases / mortality
  • Intestinal Diseases / surgery
  • Intestinal Diseases / therapy*
  • Intestinal Obstruction / complications
  • Intestine, Small / transplantation
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Parenteral Nutrition, Home*
  • Prognosis
  • Survival Rate