Meta-analysis of enteral nutrition as a primary treatment of active Crohn's disease

Gastroenterology. 1995 Apr;108(4):1056-67. doi: 10.1016/0016-5085(95)90203-1.


Background/aims: The efficacy of enteral nutrition as primary therapy of active Crohn's disease is controversial. The aim of the study was to compare by meta-analysis the likelihood of clinical response to liquid diet therapy vs. corticosteroids and to assess the importance of formula composition to efficacy.

Methods: Randomized controlled trials comparing exclusive enteral nutrition with corticosteroids and elemental with nonelemental formulas were identified through a combination of computerized and hand-searching techniques. Rates of clinical remission of active Crohn's disease, based on the intention-to-treat principle, were extracted from the studies by two independent reviewers. Odds ratios for likelihood of clinical response were calculated.

Results: In eight trials comprising 413 patients, enteral nutrition was inferior to corticosteroids (pooled odds ratio, 0.35; 95% confidence interval, 0.23-0.53). In five trials comprising 134 patients, there was no difference in the efficacy of elemental versus nonelemental formulas (pooled odds ratio, 0.87; 95% confidence interval, 0.41-1.83).

Conclusions: Corticosteroids are more effective than enteral nutrition in the treatment of active Crohn's disease. Limited sample size precludes definitive conclusions about the importance of formula composition in the efficacy of enteral nutrition; however, data analyzed in this study do not support an advantage to elemental feedings compared with a polymeric formulation.

Publication types

  • Comparative Study
  • Meta-Analysis

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Crohn Disease / drug therapy
  • Crohn Disease / therapy*
  • Enteral Nutrition*
  • Humans
  • Odds Ratio
  • Remission Induction


  • Adrenal Cortex Hormones