Impairment of rosette-forming T lymphocytes in patients with primary intracranial tumors

Cancer. 1976 Apr;37(4):1869-73. doi: 10.1002/1097-0142(197604)37:4<1869::aid-cncr2820370435>;2-q.


The percentage of T lymphocytes that form rosettes (RFC) with sheep erythrocytes (E rosettes), cutaneous delayed-type hypersensitivity, and in vitro lymphocyte transformation was measured in 15 patients with primary intracranial tumors. The ability of T lymphocytes to form E rosettes was significantly impaired. These patients also exhibited impaired ability to become sensitized to dinitrochlorobenzene and humoral suppression of PHA-induced lymphocyte blastogenesis. The hypothetical role of antibody(s) to possible shared antigenic determinants on brain and T cells is discussed.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Astrocytoma / immunology
  • Brain Neoplasms / immunology*
  • Clinical Trials as Topic
  • Dinitrochlorobenzene / immunology
  • Glioma / immunology
  • Humans
  • Hypersensitivity, Delayed / immunology
  • Immune Adherence Reaction
  • In Vitro Techniques
  • Lectins / pharmacology
  • Lymphocyte Activation
  • Male
  • Middle Aged
  • Skin Tests
  • T-Lymphocytes / immunology*


  • Dinitrochlorobenzene
  • Lectins