Viral measurement by polymerase chain reaction-based assays in human immunodeficiency virus-infected infants

J Pediatr. 1995 Apr;126(4):592-5. doi: 10.1016/s0022-3476(95)70357-8.


Serial samples from human immunodeficiency virus-infected infants in the first year of life were analyzed by quantitative human immunodeficiency virus polymerase chain reaction assays. Very high, persistent levels of plasma RNA and proviral DNA were detected throughout the study period, suggesting the absence of an effective immune response. Most patients had normal CD4 lymphocyte counts and were symptom free for the first 3 to 6 months despite high levels of viral replication. These findings support the evaluation of early intervention (before symptoms develop) and efforts to establish the predictive value of these assays.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • CD4 Lymphocyte Count
  • DNA, Viral / blood*
  • HIV / isolation & purification*
  • HIV Infections / blood
  • HIV Infections / virology*
  • Humans
  • Infant
  • Infant, Newborn
  • Polymerase Chain Reaction
  • RNA, Viral / blood*
  • Viremia / blood
  • Virus Replication


  • DNA, Viral
  • RNA, Viral