Phylogenetic relationships among transposon-like elements in human and primate DNA

J Mol Evol. 1995 Feb;40(2):127-35. doi: 10.1007/BF00167108.

Abstract

A THE-1 sequence in intron 7 of the human dystrophin gene has been found to represent a new subfamily of THE-1 elements. The sequence is closely related to the MstII family of repetitive sequences and is more like single-copy sequences found in the galago genome than any other THE-1 sequence previously reported. This new THE-1 sequence has been compared with two other complete THE-1 sequences and three related long-terminal repeat elements that we have previously found in intron 7 of the dystrophin gene, and with members of the same family from elsewhere in the primate genome. Parsimony and deletion analysis show that the cluster of THE-1 sequences in intron 7 of the dystrophin gene has arisen from at least three individual insertion events, rather than from the insertion and duplication of a single progenitor sequence.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • DNA / genetics*
  • DNA Transposable Elements / genetics*
  • Humans
  • Molecular Sequence Data
  • Phylogeny*
  • Primates / genetics*
  • Repetitive Sequences, Nucleic Acid*
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Sequence Deletion

Substances

  • DNA Transposable Elements
  • DNA

Associated data

  • GENBANK/U06836