Inhibitors of ATP-sensitive potassium channels stimulate intestinal cholecystokinin secretion

Peptides. 1994;15(8):1565-6. doi: 10.1016/0196-9781(94)90134-1.

Abstract

Recently, a role for adenosine 5'-triphosphate(ATP)-sensitive potassium channels in the regulation of cholecystokinin (CCK) secretion has been described in STC-1 cells, an intestinal CCK-secreting cell line. To examine whether a similar mechanism might participate in the regulation of hormone secretion from native CCK cells, the effects of two established inhibitors of ATP-sensitive potassium channels (e.g. glucose, disopyramide) were examined on CCK release from dispersed murine intestinal cells. Both glucose and disopyramide were found to stimulate CCK secretion. Furthermore, CCK release induced by glucose was inhibited by the calcium channel blocker diltiazem. It is concluded that, ATP-sensitive potassium channels may play a role in the regulation of intestinal CCK secretion.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine Triphosphate / pharmacology
  • Animals
  • Cell Line
  • Cholecystokinin / metabolism*
  • Diltiazem / pharmacology
  • Disopyramide / pharmacology*
  • Glucose / pharmacology*
  • Homeostasis
  • In Vitro Techniques
  • Intestinal Mucosa / drug effects
  • Intestinal Mucosa / metabolism*
  • Intestine, Small
  • Mice
  • Mice, Inbred ICR
  • Potassium Channel Blockers*
  • Potassium Channels / physiology

Substances

  • Potassium Channel Blockers
  • Potassium Channels
  • Adenosine Triphosphate
  • Cholecystokinin
  • Diltiazem
  • Disopyramide
  • Glucose