The Effect of Extracts of the Roots of the Stinging Nettle (Urtica Dioica) on the Interaction of SHBG With Its Receptor on Human Prostatic Membranes

Planta Med. 1995 Feb;61(1):31-2. doi: 10.1055/s-2006-957993.

Abstract

Extracts from the roots of the stinging nettle (Urtica dioica) are used in the treatment of benign prostatic hyperplasia. The mechanisms underlying this treatment have not been elucidated. We set out to determine whether specific extracts from U. dioica had the ability to modulate the binding of sex hormone-binding globulin to its receptor on human prostatic membranes. Four substances contained in U. dioica were examined: an aqueous extract; an alcoholic extract; U. dioica agglutinin, and stigmasta-4-en-3-one. Of these, only the aqueous extract was active. It inhibited the binding of 125I-SHBG to its receptor. The inhibition was dose related, starting at about 0.6 mg/ml and completely inhibited binding at 10 mg/ml.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Membrane / drug effects
  • Cell Membrane / metabolism
  • Humans
  • In Vitro Techniques
  • Male
  • Plant Extracts / pharmacology*
  • Prostate / drug effects*
  • Prostate / metabolism
  • Receptors, Cell Surface / drug effects*
  • Receptors, Cell Surface / metabolism
  • Sex Hormone-Binding Globulin / metabolism*

Substances

  • Plant Extracts
  • Receptors, Cell Surface
  • Sex Hormone-Binding Globulin
  • sex hormone-binding globulin receptor