Serotype switching in a partially deleted RHD gene

Vox Sang. 1994;67(4):397-401. doi: 10.1111/j.1423-0410.1994.tb01280.x.

Abstract

We have studied the RH genes in donors with the RhD-negative haplotype dCes. In contrast to the usual arrangement of genes in RhD-negative individuals, where the lack of antigen expression is due to deletion of the entire RHD gene, we find that the dCes haplotype includes an RHD gene with an internal deletion. Moreover, there appear to be no 5' sequences characteristic of RHC suggesting that the RhC antigen may be encoded by a truncated RHD or a recombinant RHD/CE gene in these dCes/dce genomes.

MeSH terms

  • African Continental Ancestry Group / genetics
  • Base Sequence
  • Blood Grouping and Crossmatching
  • DNA Mutational Analysis
  • Haplotypes / genetics
  • Humans
  • Introns
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Rh-Hr Blood-Group System / genetics*
  • Sequence Deletion*

Substances

  • Rh-Hr Blood-Group System